iEnhancer-DCLA: using the original sequence to identify enhancers and their strength based on a deep learning framework

Abstract Enhancers are small regions of DNA that bind to proteins, which enhance the transcription of genes. The enhancer may be located upstream or downstream of the gene. It is not necessarily close to the gene to be acted on, because the entanglement structure of chromatin allows the positions fa...

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Bibliographic Details
Main Authors: Meng Liao, Jian-ping Zhao, Jing Tian, Chun-Hou Zheng
Format: Article
Language:English
Published: BMC 2022-11-01
Series:BMC Bioinformatics
Subjects:
Online Access:https://doi.org/10.1186/s12859-022-05033-x