Increased levels of villus-derived exosomal miR-29a-3p in normal pregnancy than uRPL patients suppresses decidual NK cell production of interferon-γ and exerts a therapeutic effect in abortion-prone mice

Increased levels of villus-derived exosomal miR-29a-3p in normal pregnancy than uRPL patients suppresses decidual NK cell production of interferon-γ and exerts a therapeutic effect in abortion-prone mice

Abstract Objective Recurrent pregnancy loss (RPL) patients have higher absolute numbers of decidual natural killer (dNK) cells with elevated intracellular IFN-γ levels leading to a pro-inflammatory cytokine milieu, which contributes to RPL pathogenesis. The main objective of this study was twofold:...

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Bibliographic Details
Main Authors: Zheng Fang, Jiaqin Mao, Jialyu Huang, Huijun Sun, Xueyan Lu, Hui Lei, Jie Dong, Shuqiang Chen, Xiaohong Wang
Format: Article
Language:English
Published: BMC 2024-04-01
Series:Cell Communication and Signaling
Subjects:
Unexplained recurrent pregnancy loss
Decidual natural killer cell
Exosomes
Interferon-γ
miRNA
Online Access:https://doi.org/10.1186/s12964-024-01610-0

Internet

https://doi.org/10.1186/s12964-024-01610-0

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