Aprepitant attenuates NLRC4-dependent neuronal pyroptosis via NK1R/PKCδ pathway in a mouse model of intracerebral hemorrhage

Aprepitant attenuates NLRC4-dependent neuronal pyroptosis via NK1R/PKCδ pathway in a mouse model of intracerebral hemorrhage

Abstract Background Pyroptosis is a programmed cell death mediated by inflammasomes. Previous studies have reported that inhibition of neurokinin receptor 1 (NK1R) exerted neuroprotection in several neurological diseases. Herein, we have investigated the role of NK1R receptor inhibition using Aprepi...

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Bibliographic Details
Main Authors: Peng Jin, Dongqing Qi, Yuhui Cui, Cameron Lenahan, John H. Zhang, Xiaogen Tao, Shuixiang Deng, Jiping Tang
Format: Article
Language:English
Published: BMC 2022-08-01
Series:Journal of Neuroinflammation
Subjects:
Aprepitant
Intracerebral hemorrhage
Inflammasome
Neurokinin receptor 1
Pyroptosis
Online Access:https://doi.org/10.1186/s12974-022-02558-z

Internet

https://doi.org/10.1186/s12974-022-02558-z

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