Two New Plasmid Post-segregational Killing Mechanisms for the Implementation of Synthetic Gene Networks in Escherichia coli

Summary: Plasmids are the workhorse of both industrial biotechnology and synthetic biology, but ensuring they remain in bacterial cells is a challenge. Antibiotic selection cannot be used to stabilize plasmids in most real-world applications, and inserting dynamical gene networks into the genome rem...

Celý popis

Podrobná bibliografie
Hlavní autoři: Alex J.H. Fedorec, Tanel Ozdemir, Anjali Doshi, Yan-Kay Ho, Luca Rosa, Jack Rutter, Oscar Velazquez, Vitor B. Pinheiro, Tal Danino, Chris P. Barnes
Médium: Článek
Jazyk:English
Vydáno: Elsevier 2019-04-01
Edice:iScience
On-line přístup:http://www.sciencedirect.com/science/article/pii/S2589004219300859