Oxadiazole-Containing Macrocyclic Peptides Potentiate Azole Activity against Pathogenic <italic toggle="yes">Candida</italic> Species

Oxadiazole-Containing Macrocyclic Peptides Potentiate Azole Activity against Pathogenic <italic toggle="yes">Candida</italic> Species

ABSTRACT Opportunistic pathogens of the genus Candida reign as the leading cause of mycotic disease and are associated with mortality rates greater than 40%, even with antifungal intervention. This is in part due to the limited arsenal of antifungals available to treat systemic fungal infections. Az...

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Bibliographic Details
Main Authors: Nicole M. Revie, Nicole Robbins, Luke Whitesell, John R. Frost, Solomon D. Appavoo, Andrei K. Yudin, Leah E. Cowen
Format: Article
Language:English
Published: American Society for Microbiology 2020-04-01
Series:mSphere
Subjects:
Candida
Candida albicans
antifungal
azole
fluconazole
fungal pathogens
Online Access:https://journals.asm.org/doi/10.1128/mSphere.00256-20

Internet

https://journals.asm.org/doi/10.1128/mSphere.00256-20

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