High-throughput quantitation of amino acids and acylcarnitine in cerebrospinal fluid: identification of PCNSL biomarkers and potential metabolic messengers

High-throughput quantitation of amino acids and acylcarnitine in cerebrospinal fluid: identification of PCNSL biomarkers and potential metabolic messengers

Background: Due to the poor prognosis and rising occurrence, there is a crucial need to improve the diagnosis of Primary Central Nervous System Lymphoma (PCNSL), which is a rare type of non-Hodgkin’s lymphoma. This study utilized targeted metabolomics of cerebrospinal fluid (CSF) to identify biomark...

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Bibliographic Details
Main Authors: Jingjing Ma, Kun Chen, Yun Ding, Xiao Li, Qiming Tang, Bo Jin, Ruben Y. Luo, Sheeno Thyparambil, Zhi Han, C. James Chou, Ashlee Zhou, James Schilling, Zhiguang Lin, Yan Ma, Qing Li, Mengxue Zhang, Karl G. Sylvester, Seema Nagpal, Doff B. McElhinney, Xuefeng B. Ling, Bobin Chen
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-10-01
Series:Frontiers in Molecular Biosciences
Subjects:
PCNSL
cerebrospinal fluid
amino acid
acylcarnitine
UHPLC-MS/MS
Online Access:https://www.frontiersin.org/articles/10.3389/fmolb.2023.1257079/full

Internet

https://www.frontiersin.org/articles/10.3389/fmolb.2023.1257079/full

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