Tracing the origin of the NS1 A188V substitution responsible for recent enhancement of Zika virus Asian genotype infectivity

A recent study showed that infectivity of Zika virus (ZIKV) Asian genotype was enhanced by an alanine-to-valine amino acid substitution at residue 188 of the NS1 protein, but the precise time and location of origin of this mutation were not formally estimated. Here, we applied a Bayesian coalescent-...

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Bibliographic Details
Main Authors: Edson Delatorre, Daiana Mir, Gonzalo Bello
Format: Article
Language:English
Published: Fundação Oswaldo Cruz (FIOCRUZ) 2017-09-01
Series:Memorias do Instituto Oswaldo Cruz
Subjects:
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762017005008101&lng=en&tlng=en