Tracing the origin of the NS1 A188V substitution responsible for recent enhancement of Zika virus Asian genotype infectivity
A recent study showed that infectivity of Zika virus (ZIKV) Asian genotype was enhanced by an alanine-to-valine amino acid substitution at residue 188 of the NS1 protein, but the precise time and location of origin of this mutation were not formally estimated. Here, we applied a Bayesian coalescent-...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Fundação Oswaldo Cruz (FIOCRUZ)
2017-09-01
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| Series: | Memorias do Instituto Oswaldo Cruz |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762017005008101&lng=en&tlng=en |
| _version_ | 1797704804706811904 |
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| author | Edson Delatorre Daiana Mir Gonzalo Bello |
| author_facet | Edson Delatorre Daiana Mir Gonzalo Bello |
| author_sort | Edson Delatorre |
| collection | DOAJ |
| description | A recent study showed that infectivity of Zika virus (ZIKV) Asian genotype was enhanced by an alanine-to-valine amino acid substitution at residue 188 of the NS1 protein, but the precise time and location of origin of this mutation were not formally estimated. Here, we applied a Bayesian coalescent-based framework to estimate the age and location of the ancestral viral strain carrying the A188V substitution. Our results support that the ancestral ZIKV strain carrying the A188V substitution arose in Southeastern Asia at the early 2000s and circulated in that region for some time (5-10 years) before being disseminated to Southern Pacific islands and the Americas. |
| first_indexed | 2024-03-12T05:25:54Z |
| format | Article |
| id | doaj.art-7fd47bfff90e4521bf50b30193a6566d |
| institution | Directory Open Access Journal |
| issn | 1678-8060 |
| language | English |
| last_indexed | 2024-03-12T05:25:54Z |
| publishDate | 2017-09-01 |
| publisher | Fundação Oswaldo Cruz (FIOCRUZ) |
| record_format | Article |
| series | Memorias do Instituto Oswaldo Cruz |
| spelling | doaj.art-7fd47bfff90e4521bf50b30193a6566d2023-09-03T07:24:30ZengFundação Oswaldo Cruz (FIOCRUZ)Memorias do Instituto Oswaldo Cruz1678-80602017-09-01010.1590/0074-02760170299S0074-02762017005008101Tracing the origin of the NS1 A188V substitution responsible for recent enhancement of Zika virus Asian genotype infectivityEdson DelatorreDaiana MirGonzalo BelloA recent study showed that infectivity of Zika virus (ZIKV) Asian genotype was enhanced by an alanine-to-valine amino acid substitution at residue 188 of the NS1 protein, but the precise time and location of origin of this mutation were not formally estimated. Here, we applied a Bayesian coalescent-based framework to estimate the age and location of the ancestral viral strain carrying the A188V substitution. Our results support that the ancestral ZIKV strain carrying the A188V substitution arose in Southeastern Asia at the early 2000s and circulated in that region for some time (5-10 years) before being disseminated to Southern Pacific islands and the Americas.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762017005008101&lng=en&tlng=enZika VirusNS1infectivityevolution |
| spellingShingle | Edson Delatorre Daiana Mir Gonzalo Bello Tracing the origin of the NS1 A188V substitution responsible for recent enhancement of Zika virus Asian genotype infectivity Memorias do Instituto Oswaldo Cruz Zika Virus NS1 infectivity evolution |
| title | Tracing the origin of the NS1 A188V substitution responsible for recent enhancement of Zika virus Asian genotype infectivity |
| title_full | Tracing the origin of the NS1 A188V substitution responsible for recent enhancement of Zika virus Asian genotype infectivity |
| title_fullStr | Tracing the origin of the NS1 A188V substitution responsible for recent enhancement of Zika virus Asian genotype infectivity |
| title_full_unstemmed | Tracing the origin of the NS1 A188V substitution responsible for recent enhancement of Zika virus Asian genotype infectivity |
| title_short | Tracing the origin of the NS1 A188V substitution responsible for recent enhancement of Zika virus Asian genotype infectivity |
| title_sort | tracing the origin of the ns1 a188v substitution responsible for recent enhancement of zika virus asian genotype infectivity |
| topic | Zika Virus NS1 infectivity evolution |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762017005008101&lng=en&tlng=en |
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