Tracing the origin of the NS1 A188V substitution responsible for recent enhancement of Zika virus Asian genotype infectivity

Tracing the origin of the NS1 A188V substitution responsible for recent enhancement of Zika virus Asian genotype infectivity

A recent study showed that infectivity of Zika virus (ZIKV) Asian genotype was enhanced by an alanine-to-valine amino acid substitution at residue 188 of the NS1 protein, but the precise time and location of origin of this mutation were not formally estimated. Here, we applied a Bayesian coalescent-...

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Bibliographic Details
Main Authors: Edson Delatorre, Daiana Mir, Gonzalo Bello
Format: Article
Language:English
Published: Fundação Oswaldo Cruz (FIOCRUZ) 2017-09-01
Series:Memorias do Instituto Oswaldo Cruz
Subjects:
Zika Virus
NS1
infectivity
evolution
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762017005008101&lng=en&tlng=en

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