Ratio of Urinary Proteins to Albumin Excretion Shifts Substantially during Progression of the Podocytopathy Alport Syndrome, and Spot Urine Is a Reliable Method to Detect These Pathologic Changes

Ratio of Urinary Proteins to Albumin Excretion Shifts Substantially during Progression of the Podocytopathy Alport Syndrome, and Spot Urine Is a Reliable Method to Detect These Pathologic Changes

The urinary albumin- and protein-to-creatinine ratios (UACR and UPCR, respectively) are key endpoints in most clinical trials assessing risk of progression of chronic kidney disease (CKD). For the first time, the current study compares the UACR versus the UPCR head-to-head at early stages of CKD, ta...

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Bibliographic Details
Main Authors: Jan Boeckhaus, Lea Mohr, Hassan Dihazi, Burkhard Tönshoff, Lutz T. Weber, Lars Pape, Kay Latta, Henry Fehrenbach, Baerbel Lange-Sperandio, Matthias Kettwig, Hagen Staude, Sabine König, Ulrike John-Kroegel, Jutta Gellermann, Bernd Hoppe, Matthias Galiano, Dieter Haffner, Heidrun Rhode, Oliver Gross
Format: Article
Language:English
Published: MDPI AG 2023-05-01
Series:Cells
Subjects:
proteinuria
albuminuria
diagnostic marker
renal fibrosis
type IV collagen
Alport syndrome
Online Access:https://www.mdpi.com/2073-4409/12/9/1333

Internet

https://www.mdpi.com/2073-4409/12/9/1333

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