The dual pro-inflammatory and bone-protective role of calcitonin gene-related peptide alpha in age-related osteoarthritis

The dual pro-inflammatory and bone-protective role of calcitonin gene-related peptide alpha in age-related osteoarthritis

Abstract Background The vasoactive neuropeptide calcitonin gene-related peptide alpha (αCGRP) enhances nociception in primary knee osteoarthritis (OA) and has been shown to disrupt cartilage and joint integrity in experimental rheumatoid arthritis (RA). Little is known about how αCGRP may alter arti...

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Bibliographic Details
Main Authors: Alexander Hildebrandt, Tamara Dietrich, Jérôme Weber, Mara Meyer Günderoth, Sijia Zhou, Florian N. Fleckenstein, Shan Jiang, Tobias Winkler, Georg N. Duda, Serafeim Tsitsilonis, Johannes Keller, Tazio Maleitzke
Format: Article
Language:English
Published: BMC 2023-12-01
Series:Arthritis Research & Therapy
Subjects:
Calca
CGRP
Pain
Joint inflammation
Cartilage
Bone
Online Access:https://doi.org/10.1186/s13075-023-03215-3

Internet

https://doi.org/10.1186/s13075-023-03215-3

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