Cell-Permeable Succinate Rescues Mitochondrial Respiration in Cellular Models of Amiodarone Toxicity

Cell-Permeable Succinate Rescues Mitochondrial Respiration in Cellular Models of Amiodarone Toxicity

Amiodarone is a potent antiarrhythmic drug and displays substantial liver toxicity in humans. It has previously been demonstrated that amiodarone and its metabolite (desethylamiodarone, DEA) can inhibit mitochondrial function, particularly complexes I (CI) and II (CII) of the electron transport syst...

Full description

Bibliographic Details
Main Authors: Alina M. Bețiu, Imen Chamkha, Ellen Gustafsson, Elna Meijer, Vlad F. Avram, Eleonor Åsander Frostner, Johannes K. Ehinger, Lucian Petrescu, Danina M. Muntean, Eskil Elmér
Format: Article
Language:English
Published: MDPI AG 2021-10-01
Series:International Journal of Molecular Sciences
Subjects:
amiodarone
desethylamiodarone
sotalol
NV118
platelets
PBMCs
Online Access:https://www.mdpi.com/1422-0067/22/21/11786

Internet

https://www.mdpi.com/1422-0067/22/21/11786

Similar Items