Synthesis of 3,4-Di-O-benzyl-1-O-methyl-L-galactitol, a key precursor of the C33-C37 fragment of calyculins

Synthesis of 3,4-Di-O-benzyl-1-O-methyl-L-galactitol, a key precursor of the C33-C37 fragment of calyculins

3,4-Di-O-benzyl-1-O-methyl-L-galactitol (3) has been synthesized in a seven step sequence starting from 1,2:3,4-di-O-isopropylidene-alpha-D-galactopyranose (4). The synthesis involves the methyllation of HO-6 of 4, followed by methanolysis to the mixture of the corresponding methyl 6-O-methyl-alpha-...

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Bibliographic Details
Main Authors: Cironi Pablo, Varela Oscar
Format: Article
Language:English
Published: Sociedade Brasileira de Química 2001-01-01
Series:Journal of the Brazilian Chemical Society
Subjects:
calyculins
secondary metabolites
marine sponge
galactose diacetonide
L-galactitol derivative
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532001000500010

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http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532001000500010

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