Detecting protein and DNA/RNA structures in cryo-EM maps of intermediate resolution using deep learning
It is challenging to extract structural information from EM density maps at intermediate or low resolutions. Here, the authors present Emap2sec+, a program for detecting nucleotides and protein secondary structures in EM density maps at 5 to 10 Å resolution.
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2021-04-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-021-22577-3 |
| _version_ | 1818722870946168832 |
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| author | Xiao Wang Eman Alnabati Tunde W. Aderinwale Sai Raghavendra Maddhuri Venkata Subramaniya Genki Terashi Daisuke Kihara |
| author_facet | Xiao Wang Eman Alnabati Tunde W. Aderinwale Sai Raghavendra Maddhuri Venkata Subramaniya Genki Terashi Daisuke Kihara |
| author_sort | Xiao Wang |
| collection | DOAJ |
| description | It is challenging to extract structural information from EM density maps at intermediate or low resolutions. Here, the authors present Emap2sec+, a program for detecting nucleotides and protein secondary structures in EM density maps at 5 to 10 Å resolution. |
| first_indexed | 2024-12-17T21:01:30Z |
| format | Article |
| id | doaj.art-7fdf26b480c34d9188c773c5752a3afa |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-17T21:01:30Z |
| publishDate | 2021-04-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-7fdf26b480c34d9188c773c5752a3afa2022-12-21T21:32:43ZengNature PortfolioNature Communications2041-17232021-04-011211910.1038/s41467-021-22577-3Detecting protein and DNA/RNA structures in cryo-EM maps of intermediate resolution using deep learningXiao Wang0Eman Alnabati1Tunde W. Aderinwale2Sai Raghavendra Maddhuri Venkata Subramaniya3Genki Terashi4Daisuke Kihara5Department of Computer Science, Purdue UniversityDepartment of Computer Science, Purdue UniversityDepartment of Computer Science, Purdue UniversityDepartment of Computer Science, Purdue UniversityDepartment of Biological Sciences, Purdue UniversityDepartment of Computer Science, Purdue UniversityIt is challenging to extract structural information from EM density maps at intermediate or low resolutions. Here, the authors present Emap2sec+, a program for detecting nucleotides and protein secondary structures in EM density maps at 5 to 10 Å resolution.https://doi.org/10.1038/s41467-021-22577-3 |
| spellingShingle | Xiao Wang Eman Alnabati Tunde W. Aderinwale Sai Raghavendra Maddhuri Venkata Subramaniya Genki Terashi Daisuke Kihara Detecting protein and DNA/RNA structures in cryo-EM maps of intermediate resolution using deep learning Nature Communications |
| title | Detecting protein and DNA/RNA structures in cryo-EM maps of intermediate resolution using deep learning |
| title_full | Detecting protein and DNA/RNA structures in cryo-EM maps of intermediate resolution using deep learning |
| title_fullStr | Detecting protein and DNA/RNA structures in cryo-EM maps of intermediate resolution using deep learning |
| title_full_unstemmed | Detecting protein and DNA/RNA structures in cryo-EM maps of intermediate resolution using deep learning |
| title_short | Detecting protein and DNA/RNA structures in cryo-EM maps of intermediate resolution using deep learning |
| title_sort | detecting protein and dna rna structures in cryo em maps of intermediate resolution using deep learning |
| url | https://doi.org/10.1038/s41467-021-22577-3 |
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