Epigenetic DNA Modifications Upregulate SPRY2 in Human Colorectal Cancers

Epigenetic DNA Modifications Upregulate SPRY2 in Human Colorectal Cancers

Conventional wisdom is that Sprouty2 (SPRY2), a suppressor of Receptor Tyrosine Kinase (RTK) signaling, functions as a tumor suppressor and is downregulated in many solid tumors. We reported, for the first time, that increased expression of SPRY2 augments cancer phenotype and Epithelial-Mesenchymal-...

Full description

Bibliographic Details
Main Authors: Alexei J. Stuckel, Shuai Zeng, Zhen Lyu, Wei Zhang, Xu Zhang, Urszula Dougherty, Reba Mustafi, Qiong Zhang, Trupti Joshi, Marc Bissonnette, Samrat Roy Choudhury, Sharad Khare
Format: Article
Language:English
Published: MDPI AG 2021-10-01
Series:Cells
Subjects:
colorectal cancer
DNA methylation
epigenetic regulation
SPRY2 gene expression
5-hydroxymethylcytosine
CTCF transcription factor
Online Access:https://www.mdpi.com/2073-4409/10/10/2632

Internet

https://www.mdpi.com/2073-4409/10/10/2632

Similar Items