Epigenetic DNA Modifications Upregulate SPRY2 in Human Colorectal Cancers

Epigenetic DNA Modifications Upregulate SPRY2 in Human Colorectal Cancers

Conventional wisdom is that Sprouty2 (SPRY2), a suppressor of Receptor Tyrosine Kinase (RTK) signaling, functions as a tumor suppressor and is downregulated in many solid tumors. We reported, for the first time, that increased expression of SPRY2 augments cancer phenotype and Epithelial-Mesenchymal-...

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Bibliographic Details
Main Authors:	Alexei J. Stuckel, Shuai Zeng, Zhen Lyu, Wei Zhang, Xu Zhang, Urszula Dougherty, Reba Mustafi, Qiong Zhang, Trupti Joshi, Marc Bissonnette, Samrat Roy Choudhury, Sharad Khare
Format:	Article
Language:	English
Published:	MDPI AG 2021-10-01
Series:	Cells
Subjects:	colorectal cancer DNA methylation epigenetic regulation SPRY2 gene expression 5-hydroxymethylcytosine CTCF transcription factor
Online Access:	https://www.mdpi.com/2073-4409/10/10/2632

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