Olmesartan combined with renal denervation reduces blood pressure in association with sympatho-inhibitory and aldosterone-reducing effects in hypertensive mice with chronic kidney disease

Olmesartan combined with renal denervation reduces blood pressure in association with sympatho-inhibitory and aldosterone-reducing effects in hypertensive mice with chronic kidney disease

Background: Augmented sympathetic nerve activity (SNA) and renin-angiotensin-aldosterone system (RAAS) activity are involved in the pathogenesis of hypertension (HT) accompanied by chronic kidney disease (CKD). Oxidative stress in the hypothalamus increases SNA in HT. Administration of an angiotensi...

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Bibliographic Details
Main Authors: Masaaki Nishihara, Ko Takesue, Yoshitaka Hirooka
Format: Article
Language:English
Published: Taylor & Francis Group 2019-04-01
Series:Clinical and Experimental Hypertension
Subjects:
angiotensin ιι receptor blocker
renal denervation
hypertension
chronic kidney disease
sympathetic activity
renin angiotensin aldosterone system
Online Access:http://dx.doi.org/10.1080/10641963.2018.1465075

Internet

http://dx.doi.org/10.1080/10641963.2018.1465075

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