GPR183 Regulates Interferons, Autophagy, and Bacterial Growth During Mycobacterium tuberculosis Infection and Is Associated With TB Disease Severity

GPR183 Regulates Interferons, Autophagy, and Bacterial Growth During Mycobacterium tuberculosis Infection and Is Associated With TB Disease Severity

Oxidized cholesterols have emerged as important signaling molecules of immune function, but little is known about the role of these oxysterols during mycobacterial infections. We found that expression of the oxysterol-receptor GPR183 was reduced in blood from patients with tuberculosis (TB) and type...

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Bibliographic Details
Main Authors: Stacey Bartlett, Adrian Tandhyka Gemiarto, Minh Dao Ngo, Haressh Sajiir, Semira Hailu, Roma Sinha, Cheng Xiang Foo, Léanie Kleynhans, Happy Tshivhula, Tariq Webber, Helle Bielefeldt-Ohmann, Nicholas P. West, Andriette M. Hiemstra, Candice E. MacDonald, Liv von Voss Christensen, Larry S. Schlesinger, Gerhard Walzl, Mette Marie Rosenkilde, Thomas Mandrup-Poulsen, Katharina Ronacher
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-11-01
Series:Frontiers in Immunology
Subjects:
Mycobacterium tuberculosis
diabetes
oxysterols
7α,25-dihydroxycholesterol
GPR183
EBI2
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2020.601534/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2020.601534/full

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