A third dose of the unmodified COVID-19 mRNA vaccine CVnCoV enhances quality and quantity of immune responses

A third dose of the unmodified COVID-19 mRNA vaccine CVnCoV enhances quality and quantity of immune responses

A third vaccine dose is often required to achieve potent, long-lasting immune responses. We investigated the effect of three 8-μg doses of CVnCoV, CureVac’s severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccine candidate containing sequence-optimized unmodified mRNA encoding the spike...

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Bibliographic Details
Main Authors: Klara Lenart, Fredrika Hellgren, Sebastian Ols, Xianglei Yan, Alberto Cagigi, Rodrigo Arcoverde Cerveira, Inga Winge, Jakub Hanczak, Stefan O. Mueller, Edith Jasny, Kim Schwendt, Susanne Rauch, Benjamin Petsch, Karin Loré
Format: Article
Language:English
Published: Elsevier 2022-12-01
Series:Molecular Therapy: Methods & Clinical Development
Subjects:
vaccine
mRNA vaccine
antibody response
affinity maturation
vaccine biodistribution
innate immunity
Online Access:http://www.sciencedirect.com/science/article/pii/S2329050122001437

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http://www.sciencedirect.com/science/article/pii/S2329050122001437

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