Germline HLA-B evolutionary divergence influences the efficacy of immune checkpoint blockade therapy in gastrointestinal cancer

Germline HLA-B evolutionary divergence influences the efficacy of immune checkpoint blockade therapy in gastrointestinal cancer

Abstract Background The human leukocyte antigen class I (HLA-I) genotype has been linked with differential immune responses to infectious disease and cancer. However, the clinical relevance of germline HLA-mediated immunity in gastrointestinal (GI) cancer remains elusive. Methods This study retrospe...

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Bibliographic Details
Main Authors: Zhihao Lu, Huan Chen, Xi Jiao, Yujiao Wang, Lijia Wu, Huaibo Sun, Shuang Li, Jifang Gong, Jian Li, Jianling Zou, Keyan Yang, Ying Hu, Beibei Mao, Lei Zhang, Xiaotian Zhang, Zhi Peng, Ming Lu, Zhenghang Wang, Henghui Zhang, Lin Shen
Format: Article
Language:English
Published: BMC 2021-11-01
Series:Genome Medicine
Subjects:
Immune checkpoint blockade
Gastrointestinal cancer
HLA genotype
HLA-I evolutionary divergence
Tumor mutational burden
Online Access:https://doi.org/10.1186/s13073-021-00997-6

Internet

https://doi.org/10.1186/s13073-021-00997-6

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