Interferon Signaling Is Frequently Downregulated in Melanoma

Interferon Signaling Is Frequently Downregulated in Melanoma

Immune checkpoint inhibitors that block the programmed cell death protein 1/PD-L1 pathway have significantly improved the survival of patients with advanced melanoma. Immunotherapies are only effective in 15–40% of melanoma patients and resistance is associated with defects in antigen presentation a...

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Bibliographic Details
Main Authors: Sara Alavi, Ashleigh Jacqueline Stewart, Richard F. Kefford, Su Yin Lim, Elena Shklovskaya, Helen Rizos
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-06-01
Series:Frontiers in Immunology
Subjects:
melanoma
interferon
antigen presentation
immunosuppression
PD-L1
PD-L2
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2018.01414/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2018.01414/full

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