Caspase activation counteracts interferon signaling after G2 checkpoint abrogation by ATR inhibition in irradiated human cancer cells

Caspase activation counteracts interferon signaling after G2 checkpoint abrogation by ATR inhibition in irradiated human cancer cells

Recent studies suggest that inhibition of the ATR kinase can potentiate radiation-induced antitumor immune responses, but the extent and mechanisms of such responses in human cancers remain scarcely understood. We aimed to assess whether the ATR inhibitors VE822 and AZD6738, by abrogating the G2 che...

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Bibliographic Details
Main Authors: Adrian Eek Mariampillai, Sissel Hauge, Inger Øynebråten, Gro Elise Rødland, Alexandre Corthay, Randi G. Syljuåsen
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-10-01
Series:Frontiers in Oncology
Subjects:
cell cycle checkpoints
type I interferon (IFN) signaling
radiation therapy (radiotherapy)
micronuclei (MN)
ATR
caspase
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2022.981332/full

Internet

https://www.frontiersin.org/articles/10.3389/fonc.2022.981332/full

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