Tuning the immune response: sulfated archaeal glycolipid archaeosomes as an effective vaccine adjuvant for induction of humoral and cell-mediated immunity towards the SARS-CoV-2 Omicron variant of concern

Tuning the immune response: sulfated archaeal glycolipid archaeosomes as an effective vaccine adjuvant for induction of humoral and cell-mediated immunity towards the SARS-CoV-2 Omicron variant of concern

Liposomes composed of sulfated lactosyl archaeol (SLA) have been shown to be a safe and effective vaccine adjuvant with a multitude of antigens in preclinical studies. In particular, SLA-adjuvanted SARS-CoV-2 subunit vaccines based on trimeric spike protein antigens were shown to be immunogenic and...

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Bibliographic Details
Main Authors: Tyler M. Renner, Bassel Akache, Matthew Stuible, Nazanin Rohani, Yuneivy Cepero-Donates, Lise Deschatelets, Renu Dudani, Blair A. Harrison, Jason Baardsnes, Izel Koyuturk, Jennifer J. Hill, Usha D. Hemraz, Sophie Régnier, Anne E. G. Lenferink, Yves Durocher, Michael J. McCluskie
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-04-01
Series:Frontiers in Immunology
Subjects:
sulfated archaeal glycolipid (SLA)
archaeosome
adjuvant
SARS-CoV-2
spike subunit vaccine
omicron
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1182556/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2023.1182556/full

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