Human γδ T‐cell receptor repertoire is shaped by influenza viruses, age and tissue compartmentalisation

Human γδ T‐cell receptor repertoire is shaped by influenza viruses, age and tissue compartmentalisation

Abstract Background Although γδ T cells comprise up to 10% of human peripheral blood T cells, questions remain regarding their role in disease states and T‐cell receptor (TCR) clonal expansions. We dissected anti‐viral functions of human γδ T cells towards influenza viruses and defined influenza‐rea...

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Bibliographic Details
Main Authors: Sneha Sant, Misty R Jenkins, Pradyot Dash, Katherine A Watson, Zhongfang Wang, Angela Pizzolla, Marios Koutsakos, Thi HO Nguyen, Martha Lappas, Jane Crowe, Tom Loudovaris, Stuart I Mannering, Glen P Westall, Tom C Kotsimbos, Allen C Cheng, Linda Wakim, Peter C Doherty, Paul G Thomas, Liyen Loh, Katherine Kedzierska
Format: Article
Language:English
Published: Wiley 2019-01-01
Series:Clinical & Translational Immunology
Subjects:
human tissues
human γδ T cells
influenza virus infection
paired TCRγδ repertoire
public GV9‐TCRγ clonotype
Online Access:https://doi.org/10.1002/cti2.1079

Internet

https://doi.org/10.1002/cti2.1079

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