Intracellular HINT1-Assisted Hydrolysis of Nucleoside 5′-<i>O</i>-Selenophosphate Leads to the Release of Hydrogen Selenide That Exhibits Toxic Effects in Human Cervical Cancer Cells

Intracellular HINT1-Assisted Hydrolysis of Nucleoside 5′-<i>O</i>-Selenophosphate Leads to the Release of Hydrogen Selenide That Exhibits Toxic Effects in Human Cervical Cancer Cells

In this study, we present a new selenium derivative, 2′-deoxyguanosine-5′-<i>O</i>-selenophosphate (dGMPSe), synthesized by the oxathiaphospholane method and adapted here for the synthesis of nucleoside selenophosphates. Using biochemical assays (HPLC- and fluorescence-based), we investi...

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Bibliographic Details
Main Authors: Agnieszka Krakowiak, Liliana Czernek, Marta Pichlak, Renata Kaczmarek
Format: Article
Language:English
Published: MDPI AG 2022-01-01
Series:International Journal of Molecular Sciences
Subjects:
HINT1-HIstidine Triad nucleotide-binding protein 1
(d)NMPSe-nucleoside selenophosphate
(d)NMPS-nucleoside thiophosphate
cancer
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Online Access:https://www.mdpi.com/1422-0067/23/2/607

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https://www.mdpi.com/1422-0067/23/2/607

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