Targeting KCa3.1 channels to overcome erlotinib resistance in non-small cell lung cancer cells

Targeting KCa3.1 channels to overcome erlotinib resistance in non-small cell lung cancer cells

Abstract Almost all non-small cell lung cancer (NSCLC) patients initially responding to EGFR tyrosine kinase inhibitors (TKIs) develop acquired resistance. Since KCa3.1 channels, expressed in mitochondria and plasma membrane, regulate similar behavioral traits of NSCLC cells as EGFR, we hypothesized...

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Bibliographic Details
Main Authors: Luca Matteo Todesca, Matthias Gerke, Emma Etmar Bulk, Magdalena Bachmann, Alisa Rudersdorf, Lorenzo Antonuzzo, Serena Pillozzi, Martina Düfer, Ildiko Szabo, Albrecht Schwab
Format: Article
Language:English
Published: Nature Publishing Group 2024-01-01
Series:Cell Death Discovery
Online Access:https://doi.org/10.1038/s41420-023-01776-5

Internet

https://doi.org/10.1038/s41420-023-01776-5

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