Molecular and Metabolic Consequences Following E6 Transfection in an Isogenic Ovarian Cell Line (A2780) Pair

Molecular and Metabolic Consequences Following E6 Transfection in an Isogenic Ovarian Cell Line (A2780) Pair

Aims: To examine molecular and metabolic consequences of HPV-16 viral- protein E6, which targets p53 for degradation, in A2780 (ovarian cancer) cells. Methods: Isogenic derivatives of A2780 cells, with empty-vector (E6-) or E6 (E6+) transfection, were cultured. Intracellular metabolites, fatty acids...

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Bibliographic Details
Main Authors: Yuen-Li Chung, Eszter Nagy, Dominik Zietkowski, Geoffrey S. Payne, David H. Phillips, Nandita M. deSouza
Format: Article
Language:English
Published: Cell Physiol Biochem Press GmbH & Co KG 2013-11-01
Series:Cellular Physiology and Biochemistry
Subjects:
Glycerophosphocholine
Glutamine metabolism
Glucose metabolism
cPLA2
Metabolomics
HPV E6
Proton magnetic resonance spectroscopy
Online Access:http://www.karger.com/Article/FullText/356583

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http://www.karger.com/Article/FullText/356583

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