First Experimental Evidence for Reversibility of Ammonia Loss from Asparagine

First Experimental Evidence for Reversibility of Ammonia Loss from Asparagine

Ammonia loss from <sub>L</sub>-asparaginyls is a nonenzymatic reaction spontaneously occurring in all proteins and eventually resulting in damaging isoaspartate residues that hamper protein function and induce proteinopathy related to aging. Here, we discuss theoretical considerations su...

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Bibliographic Details
Main Authors: Jijing Wang, Sergey Rodin, Amir Ata Saei, Xuepei Zhang, Roman A. Zubarev
Format: Article
Language:English
Published: MDPI AG 2022-07-01
Series:International Journal of Molecular Sciences
Subjects:
deamidation
isoaspartate
anti-aging
reverse reaction
mass spectrometry
Online Access:https://www.mdpi.com/1422-0067/23/15/8371

Internet

https://www.mdpi.com/1422-0067/23/15/8371

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