First Experimental Evidence for Reversibility of Ammonia Loss from Asparagine
Ammonia loss from <sub>L</sub>-asparaginyls is a nonenzymatic reaction spontaneously occurring in all proteins and eventually resulting in damaging isoaspartate residues that hamper protein function and induce proteinopathy related to aging. Here, we discuss theoretical considerations su...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2022-07-01
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| Series: | International Journal of Molecular Sciences |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1422-0067/23/15/8371 |
| Summary: | Ammonia loss from <sub>L</sub>-asparaginyls is a nonenzymatic reaction spontaneously occurring in all proteins and eventually resulting in damaging isoaspartate residues that hamper protein function and induce proteinopathy related to aging. Here, we discuss theoretical considerations supporting the possibility of a full repair reaction and present the first experimental evidence of its existence. If confirmed, the true repair of <sub>L</sub>-asparaginyl deamidation could open new avenues for preventing aging and neurodegenerative diseases. |
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| ISSN: | 1661-6596 1422-0067 |