Preclinical immunogenicity and protective efficacy of a SARS-CoV-2 RBD-based vaccine produced with the thermophilic filamentous fungal expression system Thermothelomyces heterothallica C1

Preclinical immunogenicity and protective efficacy of a SARS-CoV-2 RBD-based vaccine produced with the thermophilic filamentous fungal expression system Thermothelomyces heterothallica C1

IntroductionThe emergency use of vaccines has been the most efficient way to control the coronavirus disease 19 (COVID-19) pandemic. However, the emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants of concern has reduced the efficacy of currently used vaccines. The rec...

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Bibliographic Details
Main Authors: Mariana Gonzalez-Hernandez, Franziska Karola Kaiser, Imke Steffen, Malgorzata Ciurkiewicz, Geert van Amerongen, Ronen Tchelet, Mark Emalfarb, Markku Saloheimo, Marilyn G. Wiebe, Marika Vitikainen, Irina C. Albulescu, Berend-Jan Bosch, Wolfgang Baumgärtner, Bart L. Haagmans, Albert D. M. E. Osterhaus
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-06-01
Series:Frontiers in Immunology
Subjects:
SARS-CoV-2
receptor-binding domain
vaccine
hamster
Thermothelomyces heterothallica
C1
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1204834/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2023.1204834/full

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