Antileishmanial metallodrugs and the elucidation of new drug targets linked to post-translational modifications machinery: pitfalls and progress

Antileishmanial metallodrugs and the elucidation of new drug targets linked to post-translational modifications machinery: pitfalls and progress

Despite the increasing number of manuscripts describing potential alternative antileishmanial compounds, little is advancing on translating these knowledges to new products to treat leishmaniasis. This is in part due to the lack of standardisations during pre-clinical drug discovery stage and also d...

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Bibliographic Details
Main Authors: Rubens Lima do Monte Neto, Paulo Otávio Lourenço Moreira, Alessandra Mara de Sousa, Miguel Antonio do Nascimento Garcia, Suellen Rodrigues Maran, Nilmar Silvio Moretti
Format: Article
Language:English
Published: Fundação Oswaldo Cruz (FIOCRUZ) 2022-03-01
Series:Memorias do Instituto Oswaldo Cruz
Subjects:
Leishmania
metallodrugs
antileishmanial
target elucidation
post-translational modifications
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762022000100857&lng=en&tlng=en

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http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762022000100857&lng=en&tlng=en

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