Simvastatin, edaravone and dexamethasone protect against kainate-induced brain endothelial cell damage

Simvastatin, edaravone and dexamethasone protect against kainate-induced brain endothelial cell damage

Abstract Background Excitotoxicity is a central pathological pathway in many neurological diseases with blood–brain barrier (BBB) dysfunction. Kainate, an exogenous excitotoxin, induces epilepsy and BBB damage in animal models, but the direct effect of kainate on brain endothelial cells has not been...

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Bibliographic Details
Main Authors: Lilla Barna, Fruzsina R. Walter, András Harazin, Alexandra Bocsik, András Kincses, Vilmos Tubak, Katalin Jósvay, Ágnes Zvara, Patricia Campos-Bedolla, Mária A. Deli
Format: Article
Language:English
Published: BMC 2020-02-01
Series:Fluids and Barriers of the CNS
Subjects:
Blood–brain barrier
Brain endothelial cells
Kainate
Simvastatin
Edaravone
Dexamethasone
Online Access:https://doi.org/10.1186/s12987-019-0166-1

Internet

https://doi.org/10.1186/s12987-019-0166-1

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