Widespread Fosfomycin Resistance in Gram-Negative Bacteria Attributable to the Chromosomal <italic toggle="yes">fosA</italic> Gene

Widespread Fosfomycin Resistance in Gram-Negative Bacteria Attributable to the Chromosomal <italic toggle="yes">fosA</italic> Gene

ABSTRACT Fosfomycin is a decades-old antibiotic which is being revisited because of its perceived activity against many extensively drug-resistant Gram-negative pathogens. FosA proteins are Mn2+ and K+-dependent glutathione S-transferases which confer fosfomycin resistance in Gram-negative bacteria...

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Bibliographic Details
Main Authors: Ryota Ito, Mustapha M. Mustapha, Adam D. Tomich, Jake D. Callaghan, Christi L. McElheny, Roberta T. Mettus, Robert M. Q. Shanks, Nicolas Sluis-Cremer, Yohei Doi
Format: Article
Language:English
Published: American Society for Microbiology 2017-09-01
Series:mBio
Subjects:
Gram negative
fosfomycin resistance
genomics
glutathione S-transferase
phylogenetics
Online Access:https://journals.asm.org/doi/10.1128/mBio.00749-17

Internet

https://journals.asm.org/doi/10.1128/mBio.00749-17

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