Late-stage modification of bioactive compounds: Improving druggability through efficient molecular editing

Late-stage modification of bioactive compounds: Improving druggability through efficient molecular editing

Synthetic chemistry plays an indispensable role in drug discovery, contributing to hit compounds identification, lead compounds optimization, candidate drugs preparation, and so on. As Nobel Prize laureate James Black emphasized, “the most fruitful basis for the discovery of a new drug is to start w...

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Bibliographic Details
Main Authors: Tongyu Huo, Xinyi Zhao, Zengrui Cheng, Jialiang Wei, Minghui Zhu, Xiaodong Dou, Ning Jiao
Format: Article
Language:English
Published: Elsevier 2024-03-01
Series:Acta Pharmaceutica Sinica B
Subjects:
Late-stage modification
Drug space
Halogenation
Oxygenation
Nitrogenation
Synthetic chemistry
Online Access:http://www.sciencedirect.com/science/article/pii/S2211383523004446

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http://www.sciencedirect.com/science/article/pii/S2211383523004446

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