Bone marrow stromal cell‐derived exosomes improve oxidative stress and pyroptosis in doxorubicin‐induced myocardial injury in vitro by regulating the transcription of GSDMD through the PI3K‐AKT‐Foxo1 pathway

Bone marrow stromal cell‐derived exosomes improve oxidative stress and pyroptosis in doxorubicin‐induced myocardial injury in vitro by regulating the transcription of GSDMD through the PI3K‐AKT‐Foxo1 pathway

Abstract Objectives Doxorubicin (DOX) can contribute to severe myocardial injury, and bone marrow stromal cells (BMSC)‐exosomes (Exos) improves acute myocardial infarction. Hence, this research investigated whether BMSC‐Exos alleviated DOX‐induced myocardial injury. Methods BMSC‐derived Exos were is...

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Bibliographic Details
Main Authors: Hong Zeng, Yong Yang, Fangfang Tou, Yuliang Zhan, Songtao Liu, Pengtao Zou, Yanmei Chen, Liang Shao
Format: Article
Language:English
Published: Wiley 2023-03-01
Series:Immunity, Inflammation and Disease
Subjects:
bone marrow stromal cells
exosomes
Foxo1
GSDMD
oxidative stress
PI3K‐AKT
Online Access:https://doi.org/10.1002/iid3.810

Internet

https://doi.org/10.1002/iid3.810

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