Digital expression profile of immune checkpoint genes in medulloblastomas identifies CD24 and CD276 as putative immunotherapy targets

Digital expression profile of immune checkpoint genes in medulloblastomas identifies CD24 and CD276 as putative immunotherapy targets

IntroductionMedulloblastoma is the most common and lethal pediatric malignant brain tumor. It comprises four main molecular subgroups: WNT-activated, SHH-activated, Group 3, and Group 4. Medulloblastoma treatment is surgical resection, craniospinal radiation, and chemotherapy. However, many patients...

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Bibliographic Details
Main Authors: Rui Ferreira Marques, Daniel Antunes Moreno, Luciane da Silva, Leticia Ferro Leal, Flávia Escremim de Paula, Iara Santana, Gustavo Teixeira, Fabiano Saggioro, Luciano Neder, Carlos Almeida Junior, Bruna Mançano, Rui Manuel Reis
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-02-01
Series:Frontiers in Immunology
Subjects:
medulloblastoma
immune checkpoints
immunotherapy
nCounter mRNA expression assay
immune profile
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1062856/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2023.1062856/full

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