Novel SK channel positive modulators prevent ferroptosis and excitotoxicity in neuronal cells

Novel SK channel positive modulators prevent ferroptosis and excitotoxicity in neuronal cells

Small conductance calcium-activated potassium (SK) channel activity has been proposed to play a role in the pathology of several neurological diseases. Besides regulating plasma membrane excitability, SK channel activation provides neuroprotection against ferroptotic cell death by reducing mitochond...

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Bibliographic Details
Main Authors: Yuequ Zhang, Shabnam Shaabani, Kirsty Vowinkel, Marina Trombetta-Lima, Angélica María Sabogal-Guáqueta, Tingting Chen, Jan Hoekstra, Jan Lembeck, Martina Schmidt, Niels Decher, Alexander Dömling, Amalia M. Dolga
Format: Article
Language:English
Published: Elsevier 2024-02-01
Series:Biomedicine & Pharmacotherapy
Subjects:
SK2 channel activators
Multicomponent reaction
GBB-3CR
Ferroptosis
Excitotoxicity
Oxidative stress
Online Access:http://www.sciencedirect.com/science/article/pii/S0753332224000441

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http://www.sciencedirect.com/science/article/pii/S0753332224000441

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