N-acetyl-L-cysteine treatment reduces beta-cell oxidative stress and pancreatic stellate cell activity in a high fat diet-induced diabetic mouse model

N-acetyl-L-cysteine treatment reduces beta-cell oxidative stress and pancreatic stellate cell activity in a high fat diet-induced diabetic mouse model

Obesity plays a major role in type II diabetes (T2DM) progression because it applies metabolic and oxidative stress resulting in dysfunctional beta-cells and activation of intra-islet pancreatic stellate cells (PaSCs) which cause islet fibrosis. Administration of antioxidant N-acetyl-L-cysteine (NAC...

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Bibliographic Details
Main Authors: Meg Schuurman, Madison Wallace, Gurleen Sahi, Malina Barillaro, Siyi Zhang, Mushfiqur Rahman, Cynthia Sawyez, Nica Borradaile, Rennian Wang
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-08-01
Series:Frontiers in Endocrinology
Subjects:
N-acetyl-L-cysteine (NAC)
HFD-induced diabetes
beta-cell oxidative stress
pancreatic stellate cells (PaSCs)
collagen fiber
Online Access:https://www.frontiersin.org/articles/10.3389/fendo.2022.938680/full

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https://www.frontiersin.org/articles/10.3389/fendo.2022.938680/full

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