Platelet-derived thrombospondin 1 promotes immune cell liver infiltration and exacerbates diet-induced steatohepatitis

Platelet-derived thrombospondin 1 promotes immune cell liver infiltration and exacerbates diet-induced steatohepatitis

Background & Aims: Recent studies have implicated platelets, particularly α-granules, in the development of non-alcoholic steatohepatitis (NASH). However, the specific mechanisms involved have yet to be determined. Notably, thrombospondin 1 (TSP1) is a major component of the platelet α-granu...

Full description

Bibliographic Details
Main Authors: Taesik Gwag, Sangderk Lee, Zhenyu Li, Alana Newcomb, Josephine Otuagomah, Steven A. Weinman, Ying Liang, Changcheng Zhou, Shuxia Wang
Format: Article
Language:English
Published: Elsevier 2024-04-01
Series:JHEP Reports
Subjects:
Platelet α granule
TSP1
NASH
brown adipocytes
organ crosstalk
Online Access:http://www.sciencedirect.com/science/article/pii/S258955592400020X

Internet

http://www.sciencedirect.com/science/article/pii/S258955592400020X

Similar Items