Dietary alterations of fatty acids of erythrocytes and mitochondria of brain and liver*
The fatty acid composition of erythrocyte and liver mitochondrial lipids was readily and drastically altered by varying the fatty acid content of the diet. Nonessential polyunsaturated fatty acids were found in these tissues when the tissue level of linoleic acid fell below 10% of the total fatty ac...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
1961-10-01
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| Series: | Journal of Lipid Research |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0022227520404882 |
| _version_ | 1818688766791909376 |
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| author | L.A. Witting C.C. Harvey B. Century M.K. Horwitt |
| author_facet | L.A. Witting C.C. Harvey B. Century M.K. Horwitt |
| author_sort | L.A. Witting |
| collection | DOAJ |
| description | The fatty acid composition of erythrocyte and liver mitochondrial lipids was readily and drastically altered by varying the fatty acid content of the diet. Nonessential polyunsaturated fatty acids were found in these tissues when the tissue level of linoleic acid fell below 10% of the total fatty acids. In essential fatty acid deficiency, two isomeric eicosatrienoic acids appeared, except when the diet supplied other more highly unsaturated nonessential fatty acids. Although brain mitochondrial lipids were relatively less affected by dietary manipulations, their fatty acid compositions could be significantly altered by variations of dietary fat; nonessential polyunsaturated fatty acids from cod liver oil were also incorporated into these lipids. It is postulated that such alterations in the polyunsaturated fatty acid content of phospholipids, other lipid complexes, or both, may be of importance in metabolism. |
| first_indexed | 2024-12-17T11:59:26Z |
| format | Article |
| id | doaj.art-80144cc0983a461bab731341168e79f0 |
| institution | Directory Open Access Journal |
| issn | 0022-2275 |
| language | English |
| last_indexed | 2024-12-17T11:59:26Z |
| publishDate | 1961-10-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Lipid Research |
| spelling | doaj.art-80144cc0983a461bab731341168e79f02022-12-21T21:49:55ZengElsevierJournal of Lipid Research0022-22751961-10-0124412418Dietary alterations of fatty acids of erythrocytes and mitochondria of brain and liver*L.A. Witting0C.C. Harvey1B. Century2M.K. Horwitt3L. B. Mendel Research Laboratory, Elgin State Hospital, Elgin, Illinois; Department of Biological Chemistry, University of Illinois College of Medicine, Chicago, IllinoisL. B. Mendel Research Laboratory, Elgin State Hospital, Elgin, Illinois; Department of Biological Chemistry, University of Illinois College of Medicine, Chicago, IllinoisL. B. Mendel Research Laboratory, Elgin State Hospital, Elgin, Illinois; Department of Biological Chemistry, University of Illinois College of Medicine, Chicago, IllinoisL. B. Mendel Research Laboratory, Elgin State Hospital, Elgin, Illinois; Department of Biological Chemistry, University of Illinois College of Medicine, Chicago, IllinoisThe fatty acid composition of erythrocyte and liver mitochondrial lipids was readily and drastically altered by varying the fatty acid content of the diet. Nonessential polyunsaturated fatty acids were found in these tissues when the tissue level of linoleic acid fell below 10% of the total fatty acids. In essential fatty acid deficiency, two isomeric eicosatrienoic acids appeared, except when the diet supplied other more highly unsaturated nonessential fatty acids. Although brain mitochondrial lipids were relatively less affected by dietary manipulations, their fatty acid compositions could be significantly altered by variations of dietary fat; nonessential polyunsaturated fatty acids from cod liver oil were also incorporated into these lipids. It is postulated that such alterations in the polyunsaturated fatty acid content of phospholipids, other lipid complexes, or both, may be of importance in metabolism.http://www.sciencedirect.com/science/article/pii/S0022227520404882 |
| spellingShingle | L.A. Witting C.C. Harvey B. Century M.K. Horwitt Dietary alterations of fatty acids of erythrocytes and mitochondria of brain and liver* Journal of Lipid Research |
| title | Dietary alterations of fatty acids of erythrocytes and mitochondria of brain and liver* |
| title_full | Dietary alterations of fatty acids of erythrocytes and mitochondria of brain and liver* |
| title_fullStr | Dietary alterations of fatty acids of erythrocytes and mitochondria of brain and liver* |
| title_full_unstemmed | Dietary alterations of fatty acids of erythrocytes and mitochondria of brain and liver* |
| title_short | Dietary alterations of fatty acids of erythrocytes and mitochondria of brain and liver* |
| title_sort | dietary alterations of fatty acids of erythrocytes and mitochondria of brain and liver |
| url | http://www.sciencedirect.com/science/article/pii/S0022227520404882 |
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