Cadmium Disrupted ER Ca<sup>2+</sup> Homeostasis by Inhibiting SERCA2 Expression and Activity to Induce Apoptosis in Renal Proximal Tubular Cells

Cadmium Disrupted ER Ca<sup>2+</sup> Homeostasis by Inhibiting SERCA2 Expression and Activity to Induce Apoptosis in Renal Proximal Tubular Cells

Cadmium (Cd<sup>2+</sup>) exposure induces chronic kidney disease and renal cancers, which originate from injury and cancerization of renal tubular cells. Previous studies have shown that Cd<sup>2+</sup> induced cytotoxicity by disrupting the intracellular Ca<sup>2+<...

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Bibliographic Details
Main Authors: Kongdong Li, Chuanzhi Guo, Jiacheng Ruan, Bo Ning, Chris Kong-Chu Wong, Haifeng Shi, Jie Gu
Format: Article
Language:English
Published: MDPI AG 2023-03-01
Series:International Journal of Molecular Sciences
Subjects:
ER stress
Ca<sup>2+</sup>
apoptosis
cadmium
Online Access:https://www.mdpi.com/1422-0067/24/6/5979

Internet

https://www.mdpi.com/1422-0067/24/6/5979

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