4-Amino-substituted Benzenesulfonamides as Inhibitors of Human Carbonic Anhydrases

4-Amino-substituted Benzenesulfonamides as Inhibitors of Human Carbonic Anhydrases

A series of N-aryl-β-alanine derivatives and diazobenzenesulfonamides containing aliphatic rings were designed, synthesized, and their binding to carbonic anhydrases (CA) I, II, VI, VII, XII, and XIII was studied by the fluorescent thermal shift assay and isothermal titration calorimetry. The result...

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Bibliographic Details
Main Authors: Kęstutis Rutkauskas, Asta Zubrienė, Ingrida Tumosienė, Kristina Kantminienė, Marytė Kažemėkaitė, Alexey Smirnov, Justina Kazokaitė, Vaida Morkūnaitė, Edita Čapkauskaitė, Elena Manakova, Saulius Gražulis, Zigmuntas J. Beresnevičius, Daumantas Matulis
Format: Article
Language:English
Published: MDPI AG 2014-10-01
Series:Molecules
Subjects:
benzenesulfonamide
hydrazide
hydrazone
azole
triazene
carbonic anhydrase
fluorescent thermal shift assay
ThermoFluor®
isothermal titration calorimetry
Online Access:http://www.mdpi.com/1420-3049/19/11/17356

Internet

http://www.mdpi.com/1420-3049/19/11/17356

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