Backpropagating Action Potentials Enable Detection of Extrasynaptic Glutamate by NMDA Receptors

Synaptic NMDA receptors (NMDARs) are crucial for neural coding and plasticity. However, little is known about the adaptive function of extrasynaptic NMDARs occurring mainly on dendritic shafts. Here, we find that in CA1 pyramidal neurons, backpropagating action potentials (bAPs) recruit shaft NMDARs...

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Bibliographic Details
Main Authors: Yu-Wei Wu, Sergei Grebenyuk, Thomas J. McHugh, Dmitri A. Rusakov, Alexey Semyanov
Format: Article
Language:English
Published: Elsevier 2012-05-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124712000927