Feasibility of breast radiation therapy in a Fanconi Anemia patient diagnosed with breast cancer: A case report and review of literature
Fanconi Anemia (FA) is a rare inherited autosomal recessive disease that results in impaired double stranded DNA repair. This leads to both increased susceptibility to various cancers, as well as hypersensitivity to radiotherapy and systemic therapy; thus, increasing the complexity of oncological tr...
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Format: | Article |
Language: | English |
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Elsevier
2021-05-01
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Series: | Clinical and Translational Radiation Oncology |
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Online Access: | http://www.sciencedirect.com/science/article/pii/S2405630821000380 |
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author | Neha Hafeez Hima Bindu Musunuru Andrew Keller Sushil Beriwal |
author_facet | Neha Hafeez Hima Bindu Musunuru Andrew Keller Sushil Beriwal |
author_sort | Neha Hafeez |
collection | DOAJ |
description | Fanconi Anemia (FA) is a rare inherited autosomal recessive disease that results in impaired double stranded DNA repair. This leads to both increased susceptibility to various cancers, as well as hypersensitivity to radiotherapy and systemic therapy; thus, increasing the complexity of oncological treatment paradigm.Here, we present an FA patient who initially developed invasive breast cancer for which she received breast conserving treatment with no significant treatment related toxicity. This was followed by a diagnosis of high-grade ductal carcinoma-in-situ in the contralateral breast, which was managed successfully by surgery and meticulously planned adjuvant radiotherapy, with no treatment interruptions. |
first_indexed | 2024-12-19T20:04:50Z |
format | Article |
id | doaj.art-8020ef5abb614186a9337b0b1fdd741f |
institution | Directory Open Access Journal |
issn | 2405-6308 |
language | English |
last_indexed | 2024-12-19T20:04:50Z |
publishDate | 2021-05-01 |
publisher | Elsevier |
record_format | Article |
series | Clinical and Translational Radiation Oncology |
spelling | doaj.art-8020ef5abb614186a9337b0b1fdd741f2022-12-21T20:07:31ZengElsevierClinical and Translational Radiation Oncology2405-63082021-05-0128129132Feasibility of breast radiation therapy in a Fanconi Anemia patient diagnosed with breast cancer: A case report and review of literatureNeha Hafeez0Hima Bindu Musunuru1Andrew Keller2Sushil Beriwal3University of Pittsburgh School of Medicine, Pittsburgh, PA, USADepartment of Radiation Oncology, UPMC Hillman Cancer Center, Pittsburgh, PA, USADepartment of Radiation Oncology, UPMC Hillman Cancer Center, Pittsburgh, PA, USADepartment of Radiation Oncology, UPMC Hillman Cancer Center, Pittsburgh, PA, USA; University of Pittsburgh School of Medicine, Pittsburgh, PA, USA; Corresponding author at: Department of Radiation Oncology, UPMC Hillman Cancer Center, 300 Halket Street, Pittsburgh, PA 15213, USA.Fanconi Anemia (FA) is a rare inherited autosomal recessive disease that results in impaired double stranded DNA repair. This leads to both increased susceptibility to various cancers, as well as hypersensitivity to radiotherapy and systemic therapy; thus, increasing the complexity of oncological treatment paradigm.Here, we present an FA patient who initially developed invasive breast cancer for which she received breast conserving treatment with no significant treatment related toxicity. This was followed by a diagnosis of high-grade ductal carcinoma-in-situ in the contralateral breast, which was managed successfully by surgery and meticulously planned adjuvant radiotherapy, with no treatment interruptions.http://www.sciencedirect.com/science/article/pii/S2405630821000380Fanconi anemiaBreast cancerRadiation therapy |
spellingShingle | Neha Hafeez Hima Bindu Musunuru Andrew Keller Sushil Beriwal Feasibility of breast radiation therapy in a Fanconi Anemia patient diagnosed with breast cancer: A case report and review of literature Clinical and Translational Radiation Oncology Fanconi anemia Breast cancer Radiation therapy |
title | Feasibility of breast radiation therapy in a Fanconi Anemia patient diagnosed with breast cancer: A case report and review of literature |
title_full | Feasibility of breast radiation therapy in a Fanconi Anemia patient diagnosed with breast cancer: A case report and review of literature |
title_fullStr | Feasibility of breast radiation therapy in a Fanconi Anemia patient diagnosed with breast cancer: A case report and review of literature |
title_full_unstemmed | Feasibility of breast radiation therapy in a Fanconi Anemia patient diagnosed with breast cancer: A case report and review of literature |
title_short | Feasibility of breast radiation therapy in a Fanconi Anemia patient diagnosed with breast cancer: A case report and review of literature |
title_sort | feasibility of breast radiation therapy in a fanconi anemia patient diagnosed with breast cancer a case report and review of literature |
topic | Fanconi anemia Breast cancer Radiation therapy |
url | http://www.sciencedirect.com/science/article/pii/S2405630821000380 |
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