Feasibility of breast radiation therapy in a Fanconi Anemia patient diagnosed with breast cancer: A case report and review of literature

Fanconi Anemia (FA) is a rare inherited autosomal recessive disease that results in impaired double stranded DNA repair. This leads to both increased susceptibility to various cancers, as well as hypersensitivity to radiotherapy and systemic therapy; thus, increasing the complexity of oncological tr...

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Main Authors: Neha Hafeez, Hima Bindu Musunuru, Andrew Keller, Sushil Beriwal
Format: Article
Language:English
Published: Elsevier 2021-05-01
Series:Clinical and Translational Radiation Oncology
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S2405630821000380
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author Neha Hafeez
Hima Bindu Musunuru
Andrew Keller
Sushil Beriwal
author_facet Neha Hafeez
Hima Bindu Musunuru
Andrew Keller
Sushil Beriwal
author_sort Neha Hafeez
collection DOAJ
description Fanconi Anemia (FA) is a rare inherited autosomal recessive disease that results in impaired double stranded DNA repair. This leads to both increased susceptibility to various cancers, as well as hypersensitivity to radiotherapy and systemic therapy; thus, increasing the complexity of oncological treatment paradigm.Here, we present an FA patient who initially developed invasive breast cancer for which she received breast conserving treatment with no significant treatment related toxicity. This was followed by a diagnosis of high-grade ductal carcinoma-in-situ in the contralateral breast, which was managed successfully by surgery and meticulously planned adjuvant radiotherapy, with no treatment interruptions.
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spelling doaj.art-8020ef5abb614186a9337b0b1fdd741f2022-12-21T20:07:31ZengElsevierClinical and Translational Radiation Oncology2405-63082021-05-0128129132Feasibility of breast radiation therapy in a Fanconi Anemia patient diagnosed with breast cancer: A case report and review of literatureNeha Hafeez0Hima Bindu Musunuru1Andrew Keller2Sushil Beriwal3University of Pittsburgh School of Medicine, Pittsburgh, PA, USADepartment of Radiation Oncology, UPMC Hillman Cancer Center, Pittsburgh, PA, USADepartment of Radiation Oncology, UPMC Hillman Cancer Center, Pittsburgh, PA, USADepartment of Radiation Oncology, UPMC Hillman Cancer Center, Pittsburgh, PA, USA; University of Pittsburgh School of Medicine, Pittsburgh, PA, USA; Corresponding author at: Department of Radiation Oncology, UPMC Hillman Cancer Center, 300 Halket Street, Pittsburgh, PA 15213, USA.Fanconi Anemia (FA) is a rare inherited autosomal recessive disease that results in impaired double stranded DNA repair. This leads to both increased susceptibility to various cancers, as well as hypersensitivity to radiotherapy and systemic therapy; thus, increasing the complexity of oncological treatment paradigm.Here, we present an FA patient who initially developed invasive breast cancer for which she received breast conserving treatment with no significant treatment related toxicity. This was followed by a diagnosis of high-grade ductal carcinoma-in-situ in the contralateral breast, which was managed successfully by surgery and meticulously planned adjuvant radiotherapy, with no treatment interruptions.http://www.sciencedirect.com/science/article/pii/S2405630821000380Fanconi anemiaBreast cancerRadiation therapy
spellingShingle Neha Hafeez
Hima Bindu Musunuru
Andrew Keller
Sushil Beriwal
Feasibility of breast radiation therapy in a Fanconi Anemia patient diagnosed with breast cancer: A case report and review of literature
Clinical and Translational Radiation Oncology
Fanconi anemia
Breast cancer
Radiation therapy
title Feasibility of breast radiation therapy in a Fanconi Anemia patient diagnosed with breast cancer: A case report and review of literature
title_full Feasibility of breast radiation therapy in a Fanconi Anemia patient diagnosed with breast cancer: A case report and review of literature
title_fullStr Feasibility of breast radiation therapy in a Fanconi Anemia patient diagnosed with breast cancer: A case report and review of literature
title_full_unstemmed Feasibility of breast radiation therapy in a Fanconi Anemia patient diagnosed with breast cancer: A case report and review of literature
title_short Feasibility of breast radiation therapy in a Fanconi Anemia patient diagnosed with breast cancer: A case report and review of literature
title_sort feasibility of breast radiation therapy in a fanconi anemia patient diagnosed with breast cancer a case report and review of literature
topic Fanconi anemia
Breast cancer
Radiation therapy
url http://www.sciencedirect.com/science/article/pii/S2405630821000380
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