Identification of NUDT15 gene variants in Amazonian Amerindians and admixed individuals from northern Brazil.

Identification of NUDT15 gene variants in Amazonian Amerindians and admixed individuals from northern Brazil.

<h4>Introduction</h4>The nudix hydrolase 15 (NUDT15) gene acts in the metabolism of thiopurine, by catabolizing its active metabolite thioguanosine triphosphate into its inactivated form, thioguanosine monophosphate. The frequency of alternative NUDT15 alleles, in particular those that c...

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Main Authors: Juliana Carla Gomes Rodrigues, Tatiane Piedade de Souza, Lucas Favacho Pastana, André Maurício Ribeiro Dos Santos, Marianne Rodrigues Fernandes, Pablo Pinto, Alayde Vieira Wanderley, Sandro José de Souza, José Eduardo Kroll, Adenilson Leão Pereira, Leandro Magalhães, Laís Reis das Mercês, Amanda Ferreira Vidal, Tatiana Vinasco-Sandoval, Giovanna Chaves Cavalcante, João Farias Guerreiro, Paulo Pimentel de Assumpção, Ândrea Ribeiro-Dos-Santos, Sidney Santos, Ney Pereira Carneiro Dos Santos
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2020-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0231651

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https://doi.org/10.1371/journal.pone.0231651

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