Testosterone Biosynthesis from 4-Androstene-3,17-Dione Catalyzed via Bifunctional Ketoreductase

Testosterone Biosynthesis from 4-Androstene-3,17-Dione Catalyzed via Bifunctional Ketoreductase

Testosterone (TS) is an important androgen drug and a precursor of steroid drug synthesis. Ketoreductase 2 (KR-2) (GenBank accession no. ABP64403.1) is observed to stereo-selectively catalyze the bioreduction of 4-androstene-3,17-dione (4-AD) to testosterone and contribute to the regeneration of NAD...

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Bibliographic Details
Main Authors: Yi Wei, Guangyao Mei, Jinlin Zhao, Shaoyang Zhang, Wenping Qin, Qing Sheng, Zhongyi Yang
Format: Article
Language:English
Published: MDPI AG 2023-11-01
Series:Fermentation
Subjects:
testosterone
bifunctional ketoreductase
NADH regeneration
enzymatic synthesis
Online Access:https://www.mdpi.com/2311-5637/9/12/998

Internet

https://www.mdpi.com/2311-5637/9/12/998

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