Knockdown of mechanosensitive adaptor Hic-5 ameliorates post-traumatic osteoarthritis in rats through repression of MMP-13

Knockdown of mechanosensitive adaptor Hic-5 ameliorates post-traumatic osteoarthritis in rats through repression of MMP-13

Abstract Osteoarthritis (OA) is the most common joint disease associated with articular cartilage destruction. Matrix metalloproteinase-13 (MMP-13) has an essential role in OA pathogenesis by degradation of collagen II, a major component of articular cartilage. Hydrogen peroxide-inducible clone-5 (H...

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Bibliographic Details
Main Authors: Aya Miyauchi, Masahito Noguchi, Xiao-Feng Lei, Masashi Sakaki, Momoko Kobayashi-Tanabe, Shogo Haraguchi, Akira Miyazaki, Joo-ri Kim-Kaneyama
Format: Article
Language:English
Published: Nature Portfolio 2023-05-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-023-34659-x

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https://doi.org/10.1038/s41598-023-34659-x

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