NHC-Ni catalyzed enantioselective synthesis of 1,4-dienes by cross-hydroalkenylation of cyclic 1,3-dienes and heterosubstituted terminal olefins

Chiral 1,4-dienes are versatile building blocks in asymmetric synthesis, therefore their production is highly sought after. Here, the authors report an efficient enantioselective cross-hydroalkenylation of cyclic 1,3-dienes and terminal olefins affording chiral 1,4-dienes by using a chiral NHC-Ni(al...

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Bibliographic Details
Main Authors: Yang Chen, Liang Dang, Chun-Yu Ho
Format: Article
Language:English
Published: Nature Portfolio 2020-05-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-020-16139-2