PI3-Kinase p110α Deficiency Modulates T Cell Homeostasis and Function and Attenuates Experimental Allergic Encephalitis in Mature Mice

PI3-Kinase p110α Deficiency Modulates T Cell Homeostasis and Function and Attenuates Experimental Allergic Encephalitis in Mature Mice

Class I phosphoinositide 3-kinases (PI3K) are involved in the development of normal and autoimmune responses, including Experimental Autoimmune Encephalomyelitis (EAE), a mouse model for human multiple sclerosis (MS). Here, the role of the ubiquitously expressed class IA PI3K p110α catalytic subunit...

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Bibliographic Details
Main Authors: José M. Rojo, María Montes-Casado, Laura Aragoneses-Fenoll, Gloria Ojeda, Umberto Dianzani, Pilar Portolés
Format: Article
Language:English
Published: MDPI AG 2021-08-01
Series:International Journal of Molecular Sciences
Subjects:
phosphatidylinositol 3-kinases
CD4<sup>+</sup> T-lymphocytes
CD4<sup>+</sup> Treg
autoimmune experimental encephalomyelitis
multiple sclerosis
Online Access:https://www.mdpi.com/1422-0067/22/16/8698

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https://www.mdpi.com/1422-0067/22/16/8698

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