Functional Depletion of HSP72 by siRNA and Quercetin Enhances Vorinostat-Induced Apoptosis in an HSP72-Overexpressing Cutaneous T-Cell Lymphoma Cell Line, Hut78

Functional Depletion of HSP72 by siRNA and Quercetin Enhances Vorinostat-Induced Apoptosis in an HSP72-Overexpressing Cutaneous T-Cell Lymphoma Cell Line, Hut78

Histone deacetylase inhibitors (HDACis) are one of the therapeutic options for cutaneous T-cell lymphoma (CTCL), but they have limited effects. We previously demonstrated that HSP72 overexpression is associated with chemoresistance to HDACis in lymphoma cells. The purpose of this study was to invest...

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Bibliographic Details
Main Authors: Kazuyasu Fujii, Masashi Idogawa, Norihiro Suzuki, Keiji Iwatsuki, Takuro Kanekura
Format: Article
Language:English
Published: MDPI AG 2021-10-01
Series:International Journal of Molecular Sciences
Subjects:
histone deacetylase inhibitor
cutaneous T-cell lymphoma
HSP72
quercetin
combination therapy
Online Access:https://www.mdpi.com/1422-0067/22/20/11258

Internet

https://www.mdpi.com/1422-0067/22/20/11258

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